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Article

Complex pattern of immune evasion in MSI colorectal cancer

27 Feb 2018

Abstract excerpt

Mismatch repair (MMR)-deficient cancers accumulate multiple insertion/deletion mutations at coding microsatellites (cMS), which give rise to frameshift peptide neoantigens. The high mutational neoantigen load of MMR-deficient cancers is reflected by pronounced anti-tumoral immune responses of the host and high responsiveness towards immune checkpoint blockade. However, immune evasion mechanisms can interfere with...

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PMID: 29900056
DOI: 10.1080/2162402x.2018.1445453

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