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Article

MHC class I antigen processing pathway defects, ras mutations and disease stage in colorectal carcinoma.

International journal of cancer - 20 Mar 2004

Atkins Derek, Breuckmann Aldona, Schmahl Gerd E, Binner Priska, Ferrone Soldano, Krummenauer Frank, Störkel Stephan, Seliger Barbara

Abstract excerpt

Colorectal tumorigenesis has been associated with the progressive acquisition of a variety of genetic alterations. These include mutations of the Ki-ras proto-oncogene in codons 12 and 13, which account for 85% of genetic changes in colorectal cancer. In murine in vitro models of oncogenic transformation, an association between ras-mediated transformation and downregulation of different components of the MHC...

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Identifiers

PMID: 14750179
DOI: 10.1002/ijc.11681

Genes

TAP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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