Article
Colorectal carcinomas in MUTYH-associated polyposis display histopathological similarities to microsatellite unstable carcinomas.
BMC cancer - 15 Jun 2009
Nielsen Maartje, de Miranda Noel F C C, van Puijenbroek Marjo, Jordanova Ekaterina S, Middeldorp Anneke, van Wezel Tom, van Eijk Ronald, Tops Carli M J, Vasen Hans F A, Hes Frederik J, Morreau Hans
Abstract excerpt
BACKGROUND: MUTYH-associated polyposis (MAP) is a recessively inherited disorder which predisposes biallelic carriers for a high risk of polyposis and colorectal carcinoma (CRC). Since about one third of the biallelic MAP patients in population based CRC series has no adenomas, this study aimed to identify specific clinicopathological characteristics of MAP CRCs and compare these with reported data on sporadic...
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