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Article

Immune evasion of microsatellite unstable colorectal cancers

2 Mar 2010

Abstract excerpt

Colorectal cancers (CRC) develop through 2 major pathways of genetic instability. In contrast to the majority of CRCs, which are characterized by chromosomal instability, high-level microsatellite unstable (MSI-H) CRCs arise as a consequence of the loss of DNA mismatch repair (MMR) functions and show accumulation of insertion and deletion mutations particularly in microsatellite sequences. MSI-H occurs in about...

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PMID: 20198617
DOI: 10.1002/ijc.25283

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