Article
Down-regulation of HLA Class I and NKG2D ligands through a concerted action of MAPK and DNA methyltransferases in colorectal cancer cells.
International journal of cancer - 1 Oct 2009
Sers Christine, Kuner Ruprecht, Falk Christine S, Lund Per, Sueltmann Holger, Braun Monika, Buness Andreas, Ruschhaupt Markus, Conrad Janine, Mang-Fatehi Shila, Stelniec Iwona, Krapfenbauer Ulf, Poustka Annemarie, Schäfer Reinhold
Abstract excerpt
Most malignant features of cancer cells are triggered by activated oncogenes and the loss of tumor suppressors due to mutation or epigenetic inactivation. It is still unclear, to what extend the escape of emerging cancer cells from recognition and elimination by the immune system is determined by similar mechanisms. We compared the transcriptomes of HCT116 colorectal cancer cells deficient in DNA...
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