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Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation.

Frontiers in immunology - 1 Jan 2021

Dhatchinamoorthy Karthik, Colbert Jeff D, Rock Kenneth L

Abstract excerpt

Major histocompatibility class I (MHC I) molecules bind peptides derived from a cell's expressed genes and then transport and display this antigenic information on the cell surface. This allows CD8 T cells to identify pathological cells that are synthesizing abnormal proteins, such as cancers that are expressing mutated proteins. In order for many cancers to arise and progress, they need to evolve mechanisms to...

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Antigen Presentation
Gene Deletion
Gene Expression Regulation, Neoplastic
Histocompatibility Antigens Class I
Killer Cells, Natural

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphocytes, Tumor-Infiltrating

Tumor Microenvironment

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Open in PubMed Open full text

Identifiers

PMID: 33767702
DOI: 10.3389/fimmu.2021.636568
PMCID: PMC7986854

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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