Article
Knock in of the AKT1 E17K mutation in human breast epithelial cells does not recapitulate oncogenic PIK3CA mutations.
Oncogene - 22 Apr 2010
Lauring J, Cosgrove D P, Fontana S, Gustin J P, Konishi H, Abukhdeir A M, Garay J P, Mohseni M, Wang G M, Higgins M J, Gorkin D, Reis M, Vogelstein B, Polyak K, Cowherd M, Buckhaults P J, Park B H
Abstract excerpt
An oncogenic mutation (G49A:E17K) in the AKT1 gene has been described recently in human breast, colon, and ovarian cancers. The low frequency of this mutation and perhaps other selective pressures have prevented the isolation of human cancer cell lines that harbor this mutation thereby limiting functional analysis. Here, we create a physiologic in vitro model to study the effects of this mutation by using somatic...
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