Article
Single-molecule LATE-PCR analysis of human mitochondrial genomic sequence variations.
PloS one - 20 May 2009
Osborne Adam, Reis Arthur H, Bach Loren, Wangh Lawrence J
Abstract excerpt
It is thought that changes in mitochondrial DNA are associated with many degenerative diseases, including Alzheimer's and diabetes. Much of the evidence, however, depends on correlating disease states with changing levels of heteroplasmy within populations of mitochondrial genomes, rather than individual mitochondrial genomes. Thus these measurements are likely to either overestimate the extent of heteroplasmy...
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