Article
Collection of isolated cells for studying mitochondrial DNA mutations within individual cells.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2009
Kraytsberg Yevgenya, Bodyak Natalya, Myerow Susan, Nicholas Alexander, Ebralidze Konstantin, Khrapko Konstantin
Abstract excerpt
Mitochondrial genome integrity is an important issue in somatic mitochondrial genetics. Development of quantitative methods is indispensable to somatic mitochondrial genetics as quantitative studies are required to characterize heteroplasmy and mutation processes, as well as their effects on phenotypic developments. This chapter outlines the methods for collecting individual cells appropriate for analysis of...
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