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Mitochondrial DNA heteroplasmy in diabetes and normal adults: role of acquired and inherited mutational patterns in twins.

Human molecular genetics - 1 Oct 2012

Avital Gal, Buchshtav Mor, Zhidkov Ilia, Tuval Feder Jeanette, Dadon Sarah, Rubin Eitan, Glass Dan, Spector Timothy D, Mishmar Dan

Abstract excerpt

Heteroplasmy, the mixture of mitochondrial genomes (mtDNA), varies among individuals and cells. Heteroplasmy levels alter the penetrance of pathological mtDNA mutations, and the susceptibility to age-related diseases such as Parkinson's disease. Although mitochondrial dysfunction occurs in age-related type 2 diabetes mellitus (T2DM), the involvement of heteroplasmy in diabetes is unclear. We hypothesized that the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22736028
DOI: 10.1093/hmg/dds245
PMCID: PMC3441121

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