Article
The role of ghrelin and ghrelin-receptor gene variants and promoter activity in type 2 diabetes.
European journal of endocrinology - 1 Aug 2009
Garcia Edwin A, King Peter, Sidhu Kally, Ohgusu Hideko, Walley Andrew, Lecoeur Cecile, Gueorguiev Maria, Khalaf Sahira, Davies Derek, Grossman Ashley B, Kojima Masayasu, Petersenn Stephan, Froguel Phillipe, Korbonits Márta
Abstract excerpt
BACKGROUND: Ghrelin and its receptor play an important role in glucose metabolism and energy homeostasis, and therefore they are functional candidates for genes carrying susceptibility alleles for type 2 diabetes. METHODS: We assessed common genetic variation of the ghrelin (GHRL; five single nucleotide polymorphisms (SNP)) and the ghrelin-receptor (GHSR) genes (four SNPs) in 610 Caucasian patients with type 2...
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