Article
Variations in the ghrelin receptor gene associate with obesity and glucose metabolism in individuals with impaired glucose tolerance.
PloS one - 13 Aug 2008
Mager Ursula, Degenhardt Tatjana, Pulkkinen Leena, Kolehmainen Marjukka, Tolppanen Anna-Maija, Lindström Jaana, Eriksson Johan G, Carlberg Carsten, Tuomilehto Jaakko, Uusitupa Matti
Abstract excerpt
BACKGROUND: Ghrelin may influence the development of obesity through its role in the control of energy balance, food intake, and regulation of body weight. The effects of ghrelin are mediated via the growth hormone secretagogue receptor (GHSR). METHODOLOGY/PRINCIPAL FINDINGS: We genotyped 7 single nucleotide polymorphisms (SNPs) in the GHSR gene and assessed the association between those SNPs and obesity and type...
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