Article
Antibody engineering reveals the important role of J segments in the production efficiency of llama single-domain antibodies in Saccharomyces cerevisiae.
Protein engineering, design & selection : PEDS - 1 Jan 2012
Gorlani A, Hulsik D Lutje, Adams H, Vriend G, Hermans P, Verrips T
Abstract excerpt
Variable domains of llama heavy-chain antibodies (VHH) are becoming a potent tool for a wide range of biotechnological and medical applications. Because of structural features typical of their single-domain nature, they are relatively easy to produce in lower eukaryotes, but it is not uncommon that some molecules have poor secretion efficiency. We therefore set out to study the production yield of VHH. We...
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