Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Induction of a mutant phenotype in human repair proficient cells after overexpression of a mutated human DNA repair gene.

Nucleic acids research - 25 Oct 1991

Belt P B, van Oosterwijk M F, Odijk H, Hoeijmakers J H, Backendorf C

Abstract excerpt

Antisense and mutated cDNA of the human excision repair gene ERCC-1 were overexpressed in repair proficient HeLa cells by means of an Epstein-Barr-virus derived cDNA expression vector. Whereas antisense RNA did not influence the survival of the transfected cells, a mutated cDNA generating an ERCC-1 protein with two extra amino acids in a conserved region of its C-terminal part resulted in a significant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Cloning, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA-Binding Proteins

Share to Molecular Sequence Data

Share to Mutation

Share to Phenotype

Share to Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 1945841
DOI: 10.1093/nar/19.20.5633
PMCID: PMC328968

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Induction of a mutant phenotype in human repair proficient cells after overexpression of a mutated human DNA repair gene.PMID 1945841Read ↗

Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange.Semantic proximity Read ↗

Proficient deoxyribonucleic acid repair of methylation damage in hamster ERCC-gene mutants.Semantic proximity Read ↗

Molecular cloning of the human DNA excision repair gene ERCC-6.Semantic proximity Read ↗

Molecular cloning and biological characterization of the human excision repair gene ERCC-3.Semantic proximity Read ↗

Overexpression and activation of the insulin receptor enhances expression of ERCC-1 messenger ribonucleic acid in cultured cells.Semantic proximity Read ↗

The human DNA repair gene, ERCC2 (XPD), corrects ultraviolet hypersensitivity and ultraviolet hypermutability of a shuttle vector replicated in xeroderma pigmentosum group D cells.Semantic proximity Read ↗

Disruption of DNA-PK in Ku80 mutant xrs-6 and the implications in DNA double-strand break repair.Semantic proximity Read ↗

Construction of human XRCC1 minigenes that fully correct the CHO DNA repair mutant EM9.Semantic proximity Read ↗

Reduction of caveolin-1 expression in tumorigenic human cell hybrids.Semantic proximity Read ↗

Overexpression of human DNA repair protein N-methylpurine-DNA glycosylase results in the increased removal of N-methylpurines in DNA without a concomitant increase in resistance to alkylating agents in Chinese hamster ovary cells.Semantic proximity Read ↗

Survival, mutagenesis, and host cell reactivation in a Chinese hamster ovary cell ERCC1 knock-out mutant.Semantic proximity Read ↗

Partial correction of the single-strand break repair defect in the CHO mutant EM9 by electroporated recombinant XRCC1 protein.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.