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Article

Mutational and functional analysis reveals ADAMTS18 metalloproteinase as a novel driver in melanoma.

Molecular cancer research : MCR - 1 Nov 2010

Wei Xiaomu, Prickett Todd D, Viloria Cristina G, Molinolo Alfredo, Lin Jimmy C, Cardenas-Navia Isabel, Cruz Pedro, Rosenberg Steven A, Davies Michael A, Gershenwald Jeffrey E, López-Otín Carlos, Samuels Yardena

Abstract excerpt

The disintegrin-metalloproteinases with thrombospondin domains (ADAMTS) genes have been suggested to function as tumor suppressors as several have been found to be epigenetically silenced in various cancers. We performed a mutational analysis of the ADAMTS gene family in human melanoma and identi...

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Source

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Identifiers

PMID: 21047771
DOI: 10.1158/1541-7786.MCR-10-0262
PMCID: PMC3058631

Genes

ADAMTS18

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21047771-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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