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Article

Protective roles of matrix metalloproteinases: from mouse models to human cancer.

Cell cycle (Georgetown, Tex.) - 15 Nov 2009

López-Otín Carlos, Palavalli Lavanya H, Samuels Yardena

Abstract excerpt

Matrix metalloproteinases (MMPs) have long been linked to cancer progression owing to their ability to breakdown tissue barriers for metastatic spread. Accordingly, multiple studies have examined the potential value of these enzymes as targets for cancer therapy. Unfortunately, most clinical trials with MMP inhibitors have yielded negative results which has made necessary to re-evaluate the role of these...

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Identifiers

PMID: 19844170
DOI: 10.4161/cc.8.22.9956
PMCID: PMC3164587

Genes

MMP8
ADAMTS15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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