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Article

Alteration in plasma testosterone levels in male mice lacking soluble epoxide hydrolase.

American journal of physiology. Endocrinology and metabolism - 1 Aug 2009

Luria Ayala, Morisseau Christophe, Tsai Hsing-Ju, Yang Jun, Inceoglu Bora, De Taeye Bart, Watkins Steven M, Wiest Michelle M, German J Bruce, Hammock Bruce D

Abstract excerpt

Soluble epoxide hydrolase (Ephx2, sEH) is a bifunctional enzyme with COOH-terminal hydrolase and NH(2)-terminal phosphatase activities. sEH converts epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatrienoic acids (DHETs), and the phosphatase activity is suggested to be involved in cholesterol metabolism. EETs participate in a wide range of biological functions, including regulation of vascular tone, renal...

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Identifiers

PMID: 19458064
DOI: 10.1152/ajpendo.00131.2009
PMCID: PMC2724109

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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