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Article

Altered behavioral phenotypes in soluble epoxide hydrolase knockout mice: effects of traumatic brain injury.

Prostaglandins & other lipid mediators - 1 Jan 2000

Strauss Kenneth I, Gruzdev Artiom, Zeldin Darryl C

Abstract excerpt

After traumatic brain injury (TBI), arachidonic acid (ArA) is released from damaged cell membranes and metabolized to many bioactive eicosanoids, including several epoxyeicosatrienoic acids (EETs). Soluble epoxide hydrolase (Ephx2, sEH) appears to be the predominant pathway for EET metabolism to less active dihydroxyeicosatrienoates (DHETs). Prior studies indicate that brain levels of EETs increase transiently...

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Identifiers

PMID: 22922090
DOI: 10.1016/j.prostaglandins.2012.07.005
PMCID: PMC3932494

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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