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Article

Impaired replication of hepatitis C virus containing mutations in a conserved NS5B retinoblastoma protein-binding motif.

Journal of virology - 1 Aug 2009

McGivern David R, Villanueva Rodrigo A, Chinnaswamy Sreedhar, Kao C Cheng, Lemon Stanley M

Abstract excerpt

Hepatitis C virus (HCV) downregulates the retinoblastoma tumor suppressor protein (Rb), a central cell cycle regulator which is also targeted by oncoproteins expressed by DNA tumor viruses. HCV genome replication is also enhanced in proliferating cells. Thus, it is possible that HCV interactions with host cell cycle regulators, such as Rb, have evolved to modify the intracellular environment to promote viral...

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Identifiers

PMID: 19458004
DOI: 10.1128/JVI.00262-09
PMCID: PMC2708619

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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