Article
Down-regulation of the retinoblastoma tumor suppressor by the hepatitis C virus NS5B RNA-dependent RNA polymerase.
Proceedings of the National Academy of Sciences of the United States of America - 13 Dec 2005
Munakata Tsubasa, Nakamura Mitsuyasu, Liang Yuqiong, Li Kui, Lemon Stanley M
Abstract excerpt
The retinoblastoma tumor-suppressor protein (Rb) plays a critical role in controlling cellular proliferation and apoptosis by regulating E2F transcription factors. Rb is a key target of oncoproteins expressed by DNA tumor viruses, but RNA viruses are not known to regulate Rb function. Here, we show that Rb abundance is negatively regulated in cells containing replicating genomic RNA from hepatitis C virus, a...
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