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Article

Genome-Wide Mutagenesis of Hepatitis C Virus Reveals Ability of Genome To Overcome Detrimental Mutations.

Journal of virology - 17 Jan 2020

Singh Deepak, Soni Shalini, Khan Shaheen, Sarangi Aditya N, Yennamalli Ragothaman M, Aggarwal Rakesh, Veerapu Naga Suresh

Abstract excerpt

To gain insight into the impact of mutations on the viability of the hepatitis C virus (HCV) genome, we created a set of full-genome mutant libraries, differing from the parent sequence as well as each other, by using a random mutagenesis approach; the proportion of mutations increased across these libraries with declining template amount or dATP concentration. The replication efficiencies of full-genome mutant...

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Identifiers

PMID: 31723027
DOI: 10.1128/JVI.01327-19
PMCID: PMC7000968

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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