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Article

Age-associated up-regulation of a negative co-stimulatory receptor PD-1 in mouse CD4+ T cells.

Experimental gerontology - 1 Aug 2009

Shimada Yukiko, Hayashi Masami, Nagasaka Yasuhiko, Ohno-Iwashita Yoshiko, Inomata Mitsushi

Abstract excerpt

To explore whether any co-stimulatory receptor(s) for TCR signaling is involved in the age-associated decline in T-cell function, we analyzed changes in these receptors in freshly isolated mouse CD4(+) T cells during aging. Both the mRNA and protein expression levels of CTLA-4 and PD-1, negative co-stimulatory receptors, increase with aging. No such changes are observed for CD28, a positive regulatory receptor....

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PMID: 19457448
DOI: 10.1016/j.exger.2009.05.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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