Article
Age-associated up-regulation of a negative co-stimulatory receptor PD-1 in mouse CD4+ T cells.
Experimental gerontology - 1 Aug 2009
Shimada Yukiko, Hayashi Masami, Nagasaka Yasuhiko, Ohno-Iwashita Yoshiko, Inomata Mitsushi
Abstract excerpt
To explore whether any co-stimulatory receptor(s) for TCR signaling is involved in the age-associated decline in T-cell function, we analyzed changes in these receptors in freshly isolated mouse CD4(+) T cells during aging. Both the mRNA and protein expression levels of CTLA-4 and PD-1, negative co-stimulatory receptors, increase with aging. No such changes are observed for CD28, a positive regulatory receptor....
Topics
- Aging
- Animals
- Antigens, Surface
- Apoptosis Regulatory Proteins
- Blotting, Western
- Immunologic Memory
- Male
- Mice
- Mice, Inbred C57BL
- Phenotype
- Programmed Cell Death 1 Receptor
- T-Lymphocytes, Regulatory
- Up-Regulation