Article
Association of a MTNR1B gene variant with fasting glucose and HOMA-B in children and adolescents with high BMI-SDS.
European journal of endocrinology - 1 Feb 2011
Holzapfel Christina, Siegrist Monika, Rank Melanie, Langhof Helmut, Grallert Harald, Baumert Jens, Irimie Corinna, Klopp Norman, Wolfarth Bernd, Illig Thomas, Hauner Hans, Halle Martin
Abstract excerpt
CONTEXT: Genome-wide association studies have shown that the melatonin receptor 1B (MTNR1B) gene locus is strongly associated with fasting glucose and β-cell function. However, data are rather limited to the adult population and normal-weight children. So far, little is known whether similar associations are present in overweight and obese children and adolescents. OBJECTIVE: The aim is to investigate an MTNR1B...
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