Article
Phenotypic CYP2A6 variation and the risk of pancreatic cancer.
JOP : Journal of the pancreas - 18 May 2009
Kadlubar Susan, Anderson Jeffrey P, Sweeney Carol, Gross Myron D, Lang Nicholas P, Kadlubar Fred F, Anderson Kristin E
Abstract excerpt
OBJECTIVE: Cytochrome P450 2A6 (CYP2A6) is an important metabolic enzyme capable of activating several procarcinogens, including dietary and tobacco-specific nitrosamines, which have been linked to pancreatic cancer. Positive associations between high CYP2A6 activity and lung and colorectal cancers have been reported. This is the first investigation of CYP2A6 activity and pancreatic cancer. DESIGN: In this...
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