Article
Genetic variation in the chromosome 17q23 amplicon and breast cancer risk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jun 2009
Kelemen Linda E, Wang Xianshu, Fredericksen Zachary S, Pankratz V Shane, Pharoah Paul D P, Ahmed Shahana, Dunning Alison M, Easton Douglas F, Vierkant Robert A, Cerhan James R, Goode Ellen L, Olson Janet E, Couch Fergus J
Abstract excerpt
BACKGROUND: Gene amplification leading to overexpression is a common event in breast tumors that is linked to tumor development and progression. The 17q23 region is amplified in >40% of breast tumors and contains several candidate oncogenes. Because common genetic variation in several oncogenes has been associated with cancer risk, we assessed the relevance of common variants in the 17q23 candidate oncogenes to...
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