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Article

Single nucleotide polymorphisms in the 20q13 amplicon genes in relation to breast cancer risk and clinical outcome.

Breast cancer research and treatment - 1 Dec 2011

Shi Hong, Bevier Melanie, Johansson Robert, Grzybowska Ewa, Chen Bowang, Eyfjörd Jorunn E, Hamann Ute, Manjer Jonas, Enquist Kerstin, Henriksson Roger, Carlson Joyce, Brandt Andreas, Lascorz Jesús, Butkiewicz Dorota, Pamula-Pilat Jolanta, Tecza Karolina, Herms Stefan, Hoffmann Per, Hemminki Kari, Lenner Per, Försti Asta

Abstract excerpt

The 20q13 region is frequently amplified/overexpressed in breast tumours. However, the nature of this amplification/overexpression is unknown. Here, we investigated genetic variation in five 20q13 amplicon genes (MYBL2, AURKA, ZNF217, STK4 and PTPN1) and its impact on breast cancer (BC) susceptibility and clinical outcome. As a novel finding, four polymorphisms in STK4 (rs6017452, rs7271519) and AURKA (rs2273535,...

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Source

Identifiers

PMID: 21630024
DOI: 10.1007/s10549-011-1600-5

Genes

AURKA
MYBL2
STK4
PTPN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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