Article
TBX2 is preferentially amplified in BRCA1- and BRCA2-related breast tumors.
Cancer research - 1 Jul 2002
Sinclair Colleen S, Adem Camilo, Naderi Ali, Soderberg Cheryl L, Johnson Michele, Wu Kangjian, Wadum Linda, Couch Vicki L, Sellers Thomas A, Schaid Daniel, Slezak Jeffrey, Fredericksen Zach, Ingle James N, Hartmann Lynn, Jenkins Robert B, Couch Fergus J
Abstract excerpt
The chromosome 17q23 region is frequently amplified in breast tumors. Gain of the region is present in 50% of BRCA1-associated breast tumors and 87% of BRCA2-associated breast tumors. The amplification frequency of the RPS6KB1 and TBX2 oncogenes from this amplicon was compared in 27 BRCA1 and BRCA2 mutant breast tumors, 15 breast tumors from high-risk patients with no BRCA1 or BRCA2 mutations, and 62 matched...
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