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Article

In vitro activity of garenoxacin against Streptococcus pneumoniae mutants with characterized resistance mechanisms.

Antimicrobial agents and chemotherapy - 1 Aug 2009

Yamamoto Kazuko, Yanagihara Katsunori, Sugahara Kazuyuki, Imamura Yoshifumi, Seki Masafumi, Izumikawa Koichi, Kakeya Hiroshi, Yamamoto Yoshihiro, Hirakata Yoichi, Kamihira Shimeru, Kohno Shigeru

Abstract excerpt

We evaluated the potency of garenoxacin in selecting resistant Streptococcus pneumoniae mutants by determining its mutant prevention concentration, using strains with and without topoisomerase gene mutations, and compared its potency to that of other quinolones. Garenoxacin had a significantly greater potency against pneumococci, including strains containing topoisomerase mutations. Genetic analysis of the S....

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Identifiers

PMID: 19451290
DOI: 10.1128/AAC.00176-09
PMCID: PMC2715604

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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