Article
In Vitro Activity of Lascufloxacin against Streptococcus pneumoniae with Mutations in the Quinolone Resistance-Determining Regions.
Antimicrobial agents and chemotherapy - 1 Apr 2018
Murata Mika, Kosai Kosuke, Yamauchi Shunsuke, Sasaki Daisuke, Kaku Norihito, Uno Naoki, Morinaga Yoshitomo, Hasegawa Hiroo, Miyazaki Taiga, Izumikawa Koichi, Mukae Hiroshi, Yanagihara Katsunori
Abstract excerpt
Lascufloxacin showed potent activity against Streptococcus pneumoniae with a GyrA or ParC mutation (first-step mutant). The frequency of selecting resistant strains tended to be lower for lascufloxacin than for levofloxacin and garenoxacin after drug exposure in first-step mutants but was similar in the comparison between lascufloxacin and moxifloxacin. The increase in MIC was smaller for lascufloxacin than for...
Topics
- Drug Resistance, Bacterial
- Fluoroquinolones
- Levofloxacin
- Microbial Sensitivity Tests
- Mutation
- Quinolones
- Streptococcus pneumoniae