Article
Activities of garenoxacin against quinolone-resistant Streptococcus pneumoniae strains in vitro and in a mouse pneumonia model.
Antimicrobial agents and chemotherapy - 1 Mar 2004
Azoulay-Dupuis E, Bédos J P, Mohler J, Peytavin G, Isturiz R, Moine P, Rieux V, Cherbuliez C, Péchère J C, Fantin B, Köhler T
Abstract excerpt
Garenoxacin is a novel des-F(6) quinolone with enhanced in vitro activities against both gram-positive and gram-negative bacteria. We compared the activity of garenoxacin with that of trovafloxacin (TVA) against Streptococcus pneumoniae, together with their efficacies and their capacities to select for resistant mutants, in a mouse model of acute pneumonia. In vitro, garenoxacin was more potent than TVA against...
Topics
- Animals
- Anti-Infective Agents
- DNA Gyrase
- DNA Topoisomerase IV
- Drug Resistance, Bacterial
- Fluoroquinolones
- Lung
- Mice
- Microbial Sensitivity Tests
- Naphthyridines