Article
Multidrug resistance in epilepsy: a pharmacogenomic update.
Expert opinion on pharmacotherapy - 1 Jul 2007
Tate Sarah K, Sisodiya Sanjay M
Abstract excerpt
Multidrug resistance is one of the most serious problems in the treatment of epilepsy and is likely to have a complex genetic and environmental basis. Various experimental data support the hypothesis that overexpression of antiepileptic drug transporters may be important. However, key questions concerning their functionality remain unanswered. The first study reporting a positive association--between genetic...
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