Article
Distinct variants at LIN28B influence growth in height from birth to adulthood.
American journal of human genetics - 14 May 2010
Widén Elisabeth, Ripatti Samuli, Cousminer Diana L, Surakka Ida, Lappalainen Tuuli, Järvelin Marjo-Riitta, Eriksson Johan G, Raitakari Olli, Salomaa Veikko, Sovio Ulla, Hartikainen Anna-Liisa, Pouta Anneli, McCarthy Mark I, Osmond Clive, Kajantie Eero, Lehtimäki Terho, Viikari Jorma, Kähönen Mika, Tyler-Smith Chris, Freimer Nelson, Hirschhorn Joel N, Peltonen Leena, Palotie Aarno
Abstract excerpt
We have studied the largely unknown genetic underpinnings of height growth by using a unique resource of longitudinal childhood height data available in Finnish population cohorts. After applying GWAS mapping of potential genes influencing pubertal height growth followed by further characterization of the genetic effects on complete postnatal growth trajectories, we have identified strong association between...
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