Article
Genetic mapping found major QTLs for antibody-induced glomerulonephritis in WKY rats.
Experimental animals - 1 Apr 2009
Kose Hiroyuki, Sado Yoshikazu, Yamada Takahisa, Matsumoto Kozo
Abstract excerpt
Genetic bases of glomerulonephritis, a major cause of kidney dysfunction in humans and one of the most characteristic complications of autoimmune disorders such as Goodpasture syndrome, are complex. The Wistar-Kyoto (WKY) rat strain is well characterized for its susceptibility to autoantibodies against glomerular basement membrane (GBM), however the molecular mechanisms underlining the phenotype are largely...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
