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Article

Strain differences and the genetic basis of experimental autoimmune anti-glomerular basement membrane glomerulonephritis.

International journal of experimental pathology - 1 Jun 2011

Reynolds John

Abstract excerpt

Goodpasture's, or anti-glomerular basement membrane (GBM), disease presents with rapidly progressive glomerulonephritis, caused by autoimmunity to a component of the GBM, the non-collagenous domain of the α3 chain of type IV collagen [α3(IV)NC1]. To investigate the mechanisms of inflammation in glomerulonephritis and to test new approaches to treatment, animal models of glomerulonephritis, termed experimental...

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Identifiers

PMID: 21342299
DOI: 10.1111/j.1365-2613.2011.00763.x
PMCID: PMC3101493

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