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Article

Functional analyses of mutants of the central core domain of an Avian Sarcoma/Leukemia Virus integrase.

Virology - 5 Dec 2011

Charmetant Julie, Moreau Karen, Gallay Kathy, Ballandras Allison, Gouet Patrice, Ronfort Corinne

Abstract excerpt

Integrase (IN) is the enzyme responsible for the integration of the retroviral genome into the host cell DNA. Herein, three mutants of conserved residues (V79, S85 and I146) of the central core domain (CCD) of an Avian Sarcoma/Leukemia Virus IN were analyzed in vitro. Our data revealed (i) the inability of S85T mutant to form dimers and tetramers in the absence of DNA and (ii) a slightly reduced ability of V79A...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 21982594
DOI: 10.1016/j.virol.2011.09.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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