Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutational analyses of the core domain of Avian Leukemia and Sarcoma Viruses integrase: critical residues for concerted integration and multimerization.

Virology - 20 Jan 2004

Moreau Karen, Faure Claudine, Violot Sébastien, Gouet Patrice, Verdier Gérard, Ronfort Corinne

Abstract excerpt

During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the cell DNA by the viral integrase (IN) enzyme. The central core domain of IN contains the catalytic site of the enzyme and is involved in binding viral ends and cell DNA as well as dimerization. We previously performed single amino acid substitutions in the core domain of an Avian Leukemia and Sarcoma Virus (ALSV) IN...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Catalytic Domain

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Integrases

Share to Models, Molecular

Share to Molecular Sequence Data

Share to Mutation

Share to Virus Integration

Share to Virus Replication

Source

Identifiers

PMID: 14972525
DOI: 10.1016/j.virol.2003.09.037

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational analyses of the core domain of Avian Leukemia and Sarcoma Viruses integrase: critical residues for concerted integration and multimerization.PMID 14972525Read ↗

Mutations in the C-terminal domain of ALSV (Avian Leukemia and Sarcoma Viruses) integrase alter the concerted DNA integration process in vitro.Semantic proximity Read ↗

Functional analyses of mutants of the central core domain of an Avian Sarcoma/Leukemia Virus integrase.Semantic proximity Read ↗

Analysis of conserved and non-conserved amino acids critical for ALSV (Avian leukemia and sarcoma viruses) integrase functions in vitro.Semantic proximity Read ↗

Avian sarcoma and leukemia virus (ASLV) integration in vitro: mutation or deletion of integrase (IN) recognition sequences does not prevent but only reduces the efficiency and accuracy of DNA integration.Semantic proximity Read ↗

Identification of Amino Acids in HIV-1 and Avian Sarcoma Virus Integrase Subsites Required for Specific Recognition of the Long Terminal Repeat EndsSemantic proximity Read ↗

Structural basis for functional tetramerization of lentiviral integrase.Semantic proximity Read ↗

Molecular mechanisms of HIV integration and therapeutic interventionSemantic proximity Read ↗

Efficient Concerted Integration by Recombinant Human Immunodeficiency Virus Type 1 Integrase without Cellular or Viral CofactorsSemantic proximity Read ↗

Minimal core domain of HIV-1 integrase for biological activity.Semantic proximity Read ↗

Changes in the mechanism of DNA integration in vitro induced by base substitutions in the HIV-1 U5 and U3 terminal sequences.Semantic proximity Read ↗

Going beyond Integration: The Emerging Role of HIV-1 Integrase in Virion MorphogenesisSemantic proximity Read ↗

Mutational scan of the human immunodeficiency virus type 2 integrase protein.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.