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Article

Retroviral integrases that are improved for processing but impaired for joining.

Virus research - 1 May 2007

Konsavage Wesley M, Sudol Malgorzata, Lee Noelle E, Katzman Michael

Abstract excerpt

Retroviral integrase specifically trims (or processes) the ends of retroviral DNA, then inserts (or joins) these ends into cellular DNA nonspecifically. We previously showed that Rous sarcoma virus integrase with a serine-to-aspartate substitution at amino acid 124 was markedly improved for processing but dramatically impaired for joining, making it the first mutant to separate the activities of integrase in this...

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Identifiers

PMID: 17289204
DOI: 10.1016/j.virusres.2007.01.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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