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Article

Insight into the ERVK Integrase – Propensity for DNA Damage

1 Dec 2016

Abstract excerpt

regions, as well as integrase (IN), which is required for retroviral integration. IN mediates viral genome insertion through 3' end processing of the viral DNA and the strand transfer reaction. This process requires the formation of a pre-integration complex, comprised of IN, viral DNA, and cellular proteins. Viral insertion causes DNA damage, leading to the requirement of host DNA repair mechanisms. Therefore, a...

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PMID: 27990140
DOI: 10.3389/fmicb.2016.01941

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