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Article

Newly synthesized curcumin analog has improved potential to prevent colorectal carcinogenesis in vivo.

Cancer science - 1 May 2009

Shibata Hiroyuki, Yamakoshi Hiroyuki, Sato Atsuko, Ohori Hisatsugu, Kakudo Yuichi, Kudo Chieko, Takahashi Yayoi, Watanabe Mika, Takano Hiroshi, Ishioka Chikashi, Noda Tetsuo, Iwabuchi Yoshiharu

Abstract excerpt

Curcumin (diferuloylmethane) has chemopreventive and chemotherapeutic potentials against various types of cancers. We have developed a series of curcumin analogs to improve its low bioavailability by enhancing its potentials. The newly synthesized analog GO-Y030 [(1E, 4E)-1,5-bis-(3,5(-bismethoxymethoxyphenyl) penta-1,4-dien-3-one] showed a 30-fold greater growth suppression in vitro via similar molecular...

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Identifiers

PMID: 19445025
DOI: 10.1111/j.1349-7006.2009.01127.x
PMCID: PMC11158762

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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