Article
Effects of propolis and gamma-cyclodextrin on intestinal neoplasia in normal weight and obese mice.
Cancer medicine - 1 Sept 2016
Cho Youngjin, Gutierrez Linda, Bordonaro Michael, Russo Daniel, Anzelmi Frank, Hooven Jayde T, Cerra Carmine, Lazarova Darina L
Abstract excerpt
Obesity is associated with colorectal cancer (CRC). This effect might be attributed to adipokine-supported signaling. We have established that propolis suppresses survival signaling in CRC cells in vitro; therefore, we ascertained the ability of a propolis supplement to modulate intestinal neoplastic development in C57BL/6J-ApcMin/+/J mice in the lean and obese state. To induce obesity, mice were fed with a...
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