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Article

Enigmol: a novel sphingolipid analogue with anticancer activity against cancer cell lines and in vivo models for intestinal and prostate cancer.

Molecular cancer therapeutics - 1 Apr 2011

Symolon Holly, Bushnev Anatoliy, Peng Qiong, Ramaraju Harsha, Mays Suzanne G, Allegood Jeremy C, Pruett Sarah T, Sullards M Cameron, Dillehay Dirck L, Liotta Dennis C, Merrill Alfred H

Abstract excerpt

Sphingoid bases are cytotoxic for many cancer cell lines and are thought to contribute to suppression of intestinal tumorigenesis in vivo by ingested sphingolipids. This study explored the behavior of a sphingoid base analogue, (2S,3S,5S)-2-amino-3,5-dihydroxyoctadecane (Enigmol), that cannot be phosphorylated by sphingosine kinases and is slowly N-acylated and therefore is more persistent than natural sphingoid...

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PMID: 21398423
DOI: 10.1158/1535-7163.MCT-10-0754
PMCID: PMC5536251

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