Article
Single nucleotide polymorphisms and clinical outcome in patients with biliary tract carcinoma treated with epirubicin, cisplatin and capecitabine.
Anticancer research - 1 May 2009
Pacetti Paola, Giovannetti Elisa, Mambrini Andrea, Nannizzi Sara, Orlandi Massimo, Tartarini Roberta, Del Freo Alfonso, Del Tacca Mario, Danesi Romano, Cantore Maurizio
Abstract excerpt
BACKGROUND: Biliary tract carcinoma (BTC) is a rare highly malignant neoplasia. Polymorphisms at the xeroderma pigmentosum group D (XPD), excision repair cross-complementing group-1 (ERCC1) and X-ray repair cross complementing group 1 (XRCC1) genes were evaluated and correlated with clinical outcome. PATIENTS AND METHODS: Thirty-three patients with BTC were treated with intravenous or intra-arterial cisplatin and...
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