Article
Single nucleotide polymorphisms in nucleotide excision repair genes XPA, XPD, XPG and ERCC1 in advanced colorectal cancer patients treated with first-line oxaliplatin/fluoropyrimidine.
Oncology - 1 Jan 2007
Monzo Mariano, Moreno Isabel, Navarro Alfons, Ibeas Rafael, Artells Rosa, Gel Bernat, Martinez Francisco, Moreno Jose, Hernandez Raquel, Navarro-Vigo Marta
Abstract excerpt
BACKGROUND/AIMS: Oxaliplatin damages the DNA, leading to apoptosis. XPA, XPD, ERCC1 and XPG genes are involved in DNA repair, and single nucleotide polymorphisms (SNPs) in these genes can influence the efficacy of oxaliplatin. We examined SNPs in these genes and correlated the results with time to progression (TTP), overall survival and response to oxaliplatin in 42 advanced colorectal cancer patients (CRC)...
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