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Article

Role of genetic polymorphisms and mutations in colorectal cancer therapy (Review).

Molecular medicine reports - 1 Jan 2000

Aiello Marco, Vella Nadia, Cannavò Calogero, Scalisi Aurora, Spandidos Demetrios A, Toffoli Giuseppe, Buonadonna Angela, Libra Massimo, Stivala Franca

Abstract excerpt

Gene polymorphisms and mutations in various types of cancer may predict clinical response to chemotherapy and related toxicity, since they may affect the metabolism of the drugs commonly used in combination chemotherapy treatments. However, conflicting data have been generated on this subject. To elucidate this issue, this review discusses the clinical applications of several genetic polymorphisms in colorectal...

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Identifiers

PMID: 21468552
DOI: 10.3892/mmr.2010.408

Genes

EGFR
GSTP1
XRCC1

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