Article
Selected base excision repair gene polymorphisms and susceptibility to biliary tract cancer and biliary stones: a population-based case-control study in China.
Carcinogenesis - 1 Jan 2008
Huang Wen-Yi, Gao Yu-Tang, Rashid Asif, Sakoda Lori C, Deng Jie, Shen Ming-Chang, Wang Bin-Sheng, Han Tian-Quan, Zhang Bai-He, Chen Bingshu E, Rosenberg Philip S, Chanock Stephen J, Hsing Ann W
Abstract excerpt
Base excision repair (BER) corrects DNA damage caused by oxidative stress and chronic inflammation, putative risk factors for cancer. To understand the relationship between genetic variation in BER genes and risk of biliary tract cancer and biliary stones, we examined non-synonymous polymorphisms in three key BER genes-x-ray repair cross-complementing group 1 (XRCC1) (R194W, rs1799782; R280H, rs25489 and R399Q,...
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