Article
XRCC1 and GSTP1 polymorphisms and prognosis of oxaliplatin-based chemotherapy in colorectal cancer: a meta-analysis.
Cancer chemotherapy and pharmacology - 1 Mar 2013
Ye Fanghui, Liu Zhenfang, Tan Aihua, Liao Ming, Mo Zengnan, Yang Xiaobo
Abstract excerpt
PURPOSE: Genetic variations are related to individual differences of DNA repair ability and drug metabolism, which can greatly influence prognosis of antineoplastic agents, such as oxaliplatin. The aim was to explore the influences of X-ray repair cross-complementing 1(XRCC1) and Glutathione S-transferase P1 (GSTP1) genetic variants on prognosis of oxaliplatin-based chemotherapy in colorectal cancer patients....
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