Article
Xeroderma pigmentosum complementation group C single-nucleotide polymorphisms in the nucleotide excision repair pathway correlate with prolonged progression-free survival in advanced ovarian cancer.
Cancer - 1 Feb 2012
Fleming Nicole D, Agadjanian Hasmik, Nassanian Hoorig, Miller Carl W, Orsulic Sandra, Karlan Beth Y, Walsh Christine S
Abstract excerpt
BACKGROUND: The nucleotide excision repair (NER) pathway is the principal DNA repair pathway for removing bulky platinum DNA adducts. Suboptimal DNA repair may lead to improved response to platinum agents. The objective of this study was to determine whether single-nucleotide polymorphisms (SNPs) in NER pathway genes could be markers of platinum response in ovarian cancer. METHODS: The authors identified patients...
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