Article
Splenic marginal zone lymphomas appear to originate from different B cell types.
The American journal of pathology - 1 Jul 2002
Bahler David W, Pindzola J Ander, Swerdlow Steven H
Abstract excerpt
Splenic marginal zone lymphomas (SMZLs) have been proposed to originate from postgerminal center memory B cells that usually have mutated immunoglobulin heavy-chain variable (VH) genes. However, the majority of SMZLs are thought to express both IgD and IgM, which is more typical of naïve B cells that have unmutated VH genes. To better define the SMZL cell of origin and pathogenesis, we studied the histological...
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