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Article

Genetic alterations in the PI3K pathway in prostate cancer.

Anticancer research - 1 May 2009

Sun Xiuju, Huang Jian, Homma Taku, Kita Daisuke, Klocker Helmut, Schafer Georg, Boyle Peter, Ohgaki Hiroko

Abstract excerpt

Alterations in the PIK3CA and PTEN genes were assessed in 40 prostate tumors (radical prostatectomy samples). Genetic analyses in glands of the highest Gleason pattern within each tumor revealed PIK3CA amplification in 13%, PIK3CA mutations in 3%, PTEN homozygous deletion in 13% and PTEN hemizygous deletion in 8% of the cases analyzed. Supporting the view that PTEN and PIK3CA act in the same PI3K signaling...

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PMID: 19443396

Genes

PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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