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Article

Coordinated transcriptional regulation of bone homeostasis by Ebf1 and Zfp521 in both mesenchymal and hematopoietic lineages.

The Journal of experimental medicine - 6 May 2013

Kiviranta Riku, Yamana Kei, Saito Hiroaki, Ho Daniel K, Laine Julius, Tarkkonen Kati, Nieminen-Pihala Vappu, Hesse Eric, Correa Diego, Määttä Jorma, Tessarollo Lino, Rosen Evan D, Horne William C, Jenkins Nancy A, Copeland Neal G, Warming Soren, Baron Roland

Abstract excerpt

Bone homeostasis is maintained by the coupled actions of hematopoietic bone-resorbing osteoclasts (OCs) and mesenchymal bone-forming osteoblasts (OBs). Here we identify early B cell factor 1 (Ebf1) and the transcriptional coregulator Zfp521 as components of the machinery that regulates bone homeostasis through coordinated effects in both lineages. Deletion of Zfp521 in OBs led to impaired bone formation and...

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Identifiers

PMID: 23569325
DOI: 10.1084/jem.20121187
PMCID: PMC3646489

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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